Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410480 | 0.91 | MEN1 (0.48) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3406529 | 0.88 | MEN1 (0.41) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3412371 | 0.87 | MEN1 (0.40) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3412246 | 0.85 | SYK (0.42) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3409991 | 0.85 | KMT2A (0.39) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3410261 | 0.83 | SYK (0.37) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3412729 | 0.83 | SYK (0.40) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3410156 | 0.83 | P2RX3 (0.38) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3410560 | 0.83 | NPC1 (0.37) | RAB9AMAPTNPC1IMPDH2GAA | |
| SCHEMBL3408803 | 0.83 | MEN1 (0.46) | MEN1KMT2ARAB9ATHRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |