Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406820 | 0.91 | L3MBTL1 (0.39) | SYKDHODHL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL3410480 | 0.85 | MEN1 (0.48) | ALDH1A1MEN1KMT2ARAB9ATHRB | |
| SCHEMBL3412354 | 0.84 | PTGS2 (0.39) | SYKTDO2ALDH1A1MAPTTP53 | |
| SCHEMBL3411225 | 0.84 | MTTP (0.41) | L3MBTL1ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL3409867 | 0.83 | MEN1 (0.41) | SYKDHODHMEN1KMT2ARAB9A | |
| SCHEMBL3409683 | 0.83 | KMT2A (0.40) | ALDH1A1MEN1KMT2ARAB9ATHRB | |
| SCHEMBL3406529 | 0.83 | MEN1 (0.41) | MEN1KMT2ARAB9ATHRBMAPT | |
| SCHEMBL3406436 | 0.83 | PLK1 (0.35) | DHODHTDO2ROCK2ROCK1 | |
| SCHEMBL3412729 | 0.83 | SYK (0.40) | SYKMEN1KMT2ARAB9ATHRB | |
| SCHEMBL3409991 | 0.81 | KMT2A (0.39) | DHODHALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |