⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28657140 | 0.75 | — | — | |
| SCHEMBL3535214 | 0.75 | ALDH1A1 (0.36) | — | |
| SCHEMBL420683 | 0.74 | — | — | |
| SCHEMBL5443235 | 0.73 | — | — | |
| SCHEMBL3963477 | 0.72 | — | — | |
| SCHEMBL13261872 | 0.72 | — | — | |
| SCHEMBL19969058 | 0.71 | — | — | |
| SCHEMBL18683149 | 0.71 | — | — | |
| SCHEMBL5011756 | 0.71 | — | — | |
| SCHEMBL195981 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018155-A1 | COMPOUND HAVING SHP2 PROTEIN DEGRADING ACTIVITY, AND MEDICAL USES THEREOF | 주식회사 유빅스테라퓨틱스 | 2023-02-16 | — | — | WO | disclosed |
| CN-110036006-A | The preparation and use of pyrimidone derivatives | 癌症研究科技有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109776522-A | Substituted heteroaryl compound and combinations thereof and purposes | 广东东阳光药业有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109608412-A | A kind of improved acotiamide hydrochloride hydrate synthetic method | 开封制药(集团)有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-109311872-A | 1H- pyrazolo [4,3-b] pyridine as PDE1 inhibitor | H.隆德贝克有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-108602798-A | The quinoline compound that 2,4,6,7- quaternarys as dnmt rna inhibitor replace | 基础应用医学研究基金会 | 2018-09-28 | — | — | CN | disclosed |
| CN-104768932-B | The heteroaryl inhibitors of PDE4 | 泰特拉探索合伙有限责任公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-107438607-A | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | 因赛特公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-107428736-A | Oneself chemotactic element inhibitor | 癌症研究科技有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107266416-A | It is used as the aryl dihydropyridone and piperidones of MGAT2 inhibitor | 百时美施贵宝公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-103827100-B | For reducing [1,2,4] thiadiazine 1,1-dioxide compound of serum uric acid | ANADYS PHARMACEUTICALS, INC. (US) | 2015-08-12 | — | — | CN | disclosed |
| CN-104781258-A | Hydroxy-substituted imidazo [1,2-a ] pyridinecarboxamides and their use as soluble guanylate cyclase stimulators | Bayer Pharma AG | 2015-07-15 | — | — | CN | disclosed |
| CN-104768932-A | Heteroaryl inhibitors of PDE4 | TETRA DISCOVERY PARTNERS LLC | 2015-07-08 | — | — | CN | disclosed |
| CN-102459185-B | Novel thyroid hormone beta receptor agonist | MITSUBISHI TANABE PHARMA CORP | 2015-06-03 | — | — | CN | disclosed |
| CN-104370909-A | Novel tricyclic compounds | ABBOTT LAB | 2015-02-25 | — | — | CN | disclosed |
| CN-101981033-B | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2015-02-04 | — | — | CN | disclosed |
| CN-102317289-A | Lactams as beta secretase inhibitors | PFIZER | 2012-01-11 | — | — | CN | disclosed |
| EP-2257169-A1 | TETRAHYDROTHIENO PYRIDINES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| CN-101790515-A | trans-3-aza-bicyclo[3.1.0]hexane derivatives | ACTELION PHARMACEUTICALS LTD | 2010-07-28 | — | — | CN | disclosed |
| WO-2009108497-A1 | TETRAHYDROTHIENO PYRIDINES | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |