Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETDB1 | Q15047 | 5/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467278 | 0.81 | SETDB1 (0.57) | SETDB1MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL1477663 | 0.80 | SETDB1 (0.56) | SETDB1MTNR1AMTNR1BNQO2 | |
| SCHEMBL1758761 | 0.80 | SETDB1 (0.56) | SETDB1MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL540605 | 0.78 | SETDB1 (0.57) | SETDB1MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL1991831 | 0.77 | SETDB1 (0.52) | SETDB1MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL4489127 | 0.77 | P2RX7 (0.54) | SETDB1MTNR1B | |
| SCHEMBL16126518 | 0.76 | SETDB1 (0.52) | SETDB1MTNR1AMTNR1BNQO2ALDH1A1 | |
| SCHEMBL16318517 | 0.75 | SETDB1 (0.51) | SETDB1MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL27928541 | 0.75 | SETDB1 (0.51) | SETDB1MTNR1AMTNR1BNPSR1NQO2 | |
| SCHEMBL16099303 | 0.75 | SETDB1 (0.51) | SETDB1MTNR1AMTNR1BNQO2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-B1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | BRICKELL BIOTECH INC (US) | 2016-01-06 | — | — | EP | disclosed |
| US-8785393-B2 | Ophthalmic pharmaceutical compositions of DP2 receptor antagonists | PANMIRA PHARMACEUTICALS, LLC (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130158036-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-06-20 | — | — | US | disclosed |
| US-20120184496-A1 | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONISTS | PANMIRA PHARMACEUTICALS, LLC (US) | 2012-07-19 | — | — | US | disclosed |
| CN-102596199-A | Ophthalmic pharmaceutical compositions of DP2 receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-07-18 | — | — | CN | disclosed |
| EP-2461809-A2 | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONISTS | Panmira Pharmaceuticals, LLC (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184496-A1 | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONISTS | PTGER2, P2RY2, TBXA2R | SETDB1 4876/4885MTNR1A 60/4885MTNR1B 67/4885 |
| US-20130158036-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER2 | SETDB1 4857/4885MTNR1A 99/4885MTNR1B 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.