Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9971076 | 1.00 | TPH1 (0.74) | TPH1 | |
| SCHEMBL307194 | 1.00 | TPH1 (0.74) | TPH1 | |
| SCHEMBL20274853 | 1.00 | TPH1 (0.74) | TPH1 | |
| SCHEMBL307195 | 1.00 | TPH1 (0.74) | TPH1 | |
| SCHEMBL308510 | 0.85 | TPH1 (1.00) | TPH1 | |
| SCHEMBL14969126 | 0.85 | TPH1 (1.00) | TPH1 | |
| SCHEMBL14969125 | 0.85 | TPH1 (1.00) | TPH1 | |
| SCHEMBL3408238 | 0.85 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308509 | 0.85 | TPH1 (1.00) | TPH1 | |
| SCHEMBL1877774 | 0.81 | TPH1 (0.60) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010062829-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR TREATING OSTEOPOROSIS | LEXICON PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | WO | disclosed |
| EP-2178536-A1 | METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-28 | — | — | EP | disclosed |
| EP-2170335-A1 | COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-2170306-A1 | METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-2170397-A1 | METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION AND RELATED DISEASES AND DISORDERS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009014972-A1 | METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN | LEXICON PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009009561-A1 | METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION AND RELATED DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009002970-A1 | COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009002964-A1 | METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |