Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 18/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873079 | 0.85 | TPH1 (0.83) | TPH1 | |
| SCHEMBL20274853 | 0.81 | TPH1 (0.74) | TPH1 | |
| SCHEMBL307194 | 0.81 | TPH1 (0.74) | TPH1 | |
| SCHEMBL9971076 | 0.81 | TPH1 (0.74) | TPH1 | |
| SCHEMBL3410236 | 0.81 | TPH1 (0.74) | TPH1 | |
| SCHEMBL307195 | 0.81 | TPH1 (0.74) | TPH1 | |
| SCHEMBL1872988 | 0.80 | TPH1 (0.70) | TPH1 | |
| SCHEMBL2237775 | 0.77 | TPH1 (0.70) | TPH1 | |
| SCHEMBL1129389 | 0.77 | TPH1 (0.70) | TPH1 | |
| SCHEMBL1131298 | 0.76 | TPH1 (0.68) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496231-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER | Lexicon Pharmaceuticals, Inc. (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056916-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-12 | — | — | WO | disclosed |