SCHEMBL3411538

SCHEMBL3411538

NC1(OCc2ccccc2)CCCC1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45
IDO1 P14902 1/20 0.45
AGXT P21549 1/20 0.43
OPRM1 P35372 1/20 0.43
OPRD1 P41143 1/20 0.43
OPRK1 P41145 1/20 0.43
OPRL1 P41146 1/20 0.43
TSHR P16473 1/20 0.43
DHFR P00374 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3985723 0.98 MAOA (0.44) MAOAMAOBIDO1AGXTOPRM1
SCHEMBL10942039 0.78 TSHR (0.44) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL21638945 0.76 TSHR (0.43) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL2237483 0.74 TSHR (0.41) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL11587465 0.74 TSHR (0.41) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL11540623 0.74 TSHR (0.41) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL19745328 0.73 SLC1A3 (0.45) TSHR
SCHEMBL5139043 0.72 TSHR (0.43) IDO1AGXTOPRM1OPRD1OPRK1
SCHEMBL31187955 0.72 MAOA (0.45) MAOAMAOBIDO1TSHR
SCHEMBL3645094 0.72 DHFR (0.38) IDO1DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2259790-A1 ABCA-1 ELEVATING COMPOUNDS AND THE USE THEREOF Gilead Palo Alto, Inc. (US) 2010-12-15 EP disclosed
EP-2146967-A2 TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES Serenex, Inc. (US) 2010-01-27 EP disclosed
WO-2009100326-A1 ABCA-1 ELEVATING COMPOUNDS AND THE USE THEREOF CV THERAPEUTICS, INC. (US) 2009-08-13 WO disclosed
WO-2008130879-A2 TETRAHYDROINDOLE AND TETRAHYDROINDAZOLE DERIVATIVES SERENEX, INC. (US) 2008-10-30 WO disclosed
EP-1633348-B1 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES ELAN PHARM INC (US) 2008-10-08 EP disclosed
EP-1789431-A1 PARTIAL AND FULL AGONISTS OF A1 ADENOSINE RECEPTORS CV THERAPEUTICS, INC. (US) 2007-05-30 EP disclosed
EP-1768991-A1 PROCESS FOR THE PREPARATION OF A1-ADENOSINE RECEPTOR AGONISTS CV THERAPEUTICS, INC. (US) 2007-04-04 EP disclosed
WO-2006026651-A1 PARTIAL AND FULL AGONISTS OF A1 ADENOSINE RECEPTORS CV THERAPEUTICS, INC. (US) 2006-03-09 WO disclosed
WO-2006017052-A1 PROCESS FOR THE PREPARATION OF A1 ADENOSINE RECEPTOR AGONISTS CV THERAPEUTICS, INC. (US) 2006-02-16 WO disclosed
EP-1334087-A1 CYCLOALKYLFLUOROSULFONAMIDE DERIVATIVES ELI LILLY AND COMPANY (US) 2003-08-13 EP disclosed
WO-2002032858-A1 CYCLOALKYLFLUOROSULFONAMIDE DERIVATIVES ELI LILLY AND COMPANY (US) 2002-04-25 WO disclosed