Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412879 | 0.83 | MAPT (0.42) | MAPTPOLBGAAABCB1ABCC1 | |
| SCHEMBL3412595 | 0.81 | MAPT (0.41) | MAPTPOLBABCB1ABCC1ABCG2 | |
| SCHEMBL3412202 | 0.81 | MAPT (0.42) | MAPTPOLBABCB1ABCC1ABCG2 | |
| SCHEMBL3408803 | 0.80 | MEN1 (0.46) | KMT2AMEN1HPGDKDM4ERXFP1 | |
| SCHEMBL3407955 | 0.79 | NPC1 (0.51) | MAPTKMT2AMEN1GAAHPGD | |
| SCHEMBL3407207 | 0.77 | PSEN1 (0.43) | MAPTPOLBNPSR1ABCB1ABCC1 | |
| SCHEMBL4095533 | 0.75 | PSEN1 (0.53) | — | |
| SCHEMBL3410260 | 0.75 | NPC1 (0.53) | MAPTKMT2AMEN1GAAHPGD | |
| SCHEMBL3410452 | 0.75 | BRAF (0.44) | MAPTKMT2AMEN1POLBABCB1 | |
| SCHEMBL3410480 | 0.74 | MEN1 (0.48) | MAPTKMT2AMEN1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |