Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 8/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410817 | 0.84 | GALR2 (0.39) | ABCG2ABCB1ABCC1 | |
| SCHEMBL3412641 | 0.83 | MAPT (0.42) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3412595 | 0.82 | MAPT (0.41) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3407207 | 0.82 | PSEN1 (0.43) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3412202 | 0.82 | MAPT (0.42) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3407955 | 0.80 | NPC1 (0.51) | MAPTABCG2NPC1RAB9AGAA | |
| SCHEMBL3411256 | 0.79 | ABCB1 (0.40) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3410260 | 0.76 | NPC1 (0.53) | MAPTABCG2NPC1RAB9AGAA | |
| SCHEMBL3410452 | 0.75 | BRAF (0.44) | MAPTABCG2ABCB1ABCC1POLB | |
| SCHEMBL3410953 | 0.75 | ABCB1 (0.44) | MAPTABCG2ABCB1ABCC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |