Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410260 | 0.92 | NPC1 (0.53) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3406068 | 0.87 | NPC1 (0.46) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3408803 | 0.85 | MEN1 (0.46) | NPC1RAB9AKCNH2DOT1LIMPDH2 | |
| SCHEMBL3410316 | 0.85 | IMPDH2 (0.44) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3411066 | 0.84 | NPC1 (0.47) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3410885 | 0.84 | NPC1 (0.44) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3408862 | 0.84 | NPC1 (0.43) | NPC1RAB9AKCNH2DOT1LBRD4 | |
| SCHEMBL3410702 | 0.83 | USP2 (0.45) | NPC1RAB9AKCNH2DOT1LMAPT | |
| SCHEMBL3409949 | 0.83 | IMPDH2 (0.51) | NPC1RAB9AKCNH2DOT1LIMPDH2 | |
| SCHEMBL3411085 | 0.83 | NPC1 (0.42) | NPC1RAB9AKCNH2DOT1LMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |