Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475796 | 0.88 | TRPC5 (0.46) | KDM5AGRIN1GRIN2BTRPC5BRD4 | |
| SCHEMBL3476109 | 0.87 | BRD4 (0.47) | KDM5AGRIN1GRIN2BTRPC5BRD4 | |
| SCHEMBL3380569 | 0.86 | FFAR4 (0.45) | KDM5AGRIN1GRIN2BTRPC5BRD4 | |
| SCHEMBL3379857 | 0.85 | KDM5A (0.43) | KDM5APIK3CBPRKDCATMATR | |
| SCHEMBL3434810 | 0.82 | SCD (0.46) | GRIN1GRIN2BTRPC5MAP4K1TRPV3 | |
| SCHEMBL3434978 | 0.79 | AAK1 (0.42) | KDM5ABRD4P2RX3 | |
| SCHEMBL3474602 | 0.78 | BRD4 (0.49) | BRD4 | |
| SCHEMBL3475811 | 0.77 | GCGR (0.41) | BRD4 | |
| SCHEMBL3376728 | 0.76 | TDP2 (0.42) | KDM5ABRD4CYP3A4 | |
| SCHEMBL3473822 | 0.74 | FFAR1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |