Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479060 | 0.90 | F11 (0.51) | F11SMN1; SMN2NPC1RAB9AGABRG2 | |
| SCHEMBL3413549 | 0.80 | F11 (0.42) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL479102 | 0.78 | F11 (0.51) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL479101 | 0.78 | F11 (0.51) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL478787 | 0.76 | F11 (0.52) | F11SMN1; SMN2NPC1RAB9AKLKB1 | |
| SCHEMBL3414032 | 0.76 | PDE4A (0.42) | F11SMN1; SMN2HPGDROCK1MYLK4 | |
| SCHEMBL3413708 | 0.75 | F11 (0.40) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL4707261 | 0.74 | F11 (0.49) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL478940 | 0.74 | F11 (0.41) | F11SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL478939 | 0.74 | F11 (0.41) | F11SMN1; SMN2NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |