Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 5/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.48 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196058 | 0.80 | F11 (0.62) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3614814 | 0.80 | PORCN (0.48) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3413708 | 0.79 | F11 (0.40) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL14072802 | 0.79 | PORCN (0.49) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL478939 | 0.78 | F11 (0.41) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL478940 | 0.78 | F11 (0.41) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL16927500 | 0.77 | PORCN (0.47) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3413631 | 0.77 | PDGFRB (0.41) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3414366 | 0.74 | F11 (0.44) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL3413549 | 0.74 | F11 (0.42) | F11KLKB1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981854-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007070826-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |