Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.53 |
| ▸ | MST1R | Q04912 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410098 | 0.90 | MET (0.64) | METMST1RCYP3A4 | |
| SCHEMBL2421183 | 0.87 | MET (0.69) | METMST1RCYP3A4 | |
| SCHEMBL12287364 | 0.82 | MET (0.60) | METMST1RCYP3A4CCNCCDK8 | |
| SCHEMBL2421326 | 0.80 | CCNC (0.42) | METCCNCCDK8 | |
| SCHEMBL2422079 | 0.78 | MET (0.84) | METMST1RCYP3A4 | |
| SCHEMBL1821346 | 0.76 | MAP4K3 (0.61) | METMST1R | |
| SCHEMBL16245172 | 0.74 | MET (0.49) | METMST1RCCNCCDK8 | |
| SCHEMBL16245284 | 0.74 | MET (0.51) | METMST1R | |
| SCHEMBL2422796 | 0.74 | MET (0.62) | METMST1RCYP3A4 | |
| SCHEMBL2422793 | 0.74 | MET (0.62) | METMST1RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |