Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.64 |
| ▸ | MST1R | Q04912 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414601 | 0.90 | MET (0.53) | METMST1RCYP3A4 | |
| SCHEMBL2422079 | 0.86 | MET (0.84) | METMST1RCYP3A4 | |
| SCHEMBL1821346 | 0.83 | MAP4K3 (0.61) | METMST1RJAK2MAP4K3 | |
| SCHEMBL3416213 | 0.82 | MET (0.46) | METMST1R | |
| SCHEMBL2421687 | 0.82 | MET (0.75) | METMST1RCYP3A4 | |
| SCHEMBL2421963 | 0.79 | MET (0.87) | METMST1RCYP3A4 | |
| SCHEMBL2419830 | 0.78 | MET (1.00) | METMST1RCYP3A4JAK2MAP4K3 | |
| SCHEMBL2421183 | 0.78 | MET (0.69) | METMST1RCYP3A4 | |
| SCHEMBL2424779 | 0.77 | MET (1.00) | METMST1RCYP3A4 | |
| SCHEMBL2424515 | 0.77 | MET (0.90) | METMST1RCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265616-A1 | FURO-AND THIENO[3,2-C]PYRIDINES | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009100282-A1 | FURO-AND THIENO[3,2-C] PYRIDINES | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |