Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181941 | 0.88 | GPR119 (0.36) | USP14 | |
| SCHEMBL2184101 | 0.87 | CYP11B1 (0.41) | USP14 | |
| SCHEMBL2182535 | 0.85 | USP14 (0.35) | USP14PARP14 | |
| SCHEMBL2184534 | 0.83 | HSP90AA1 (0.37) | USP14PARP14 | |
| SCHEMBL2184425 | 0.82 | HSP90AA1 (0.47) | USP14 | |
| SCHEMBL3417339 | 0.82 | HSP90AA1 (0.47) | USP14 | |
| SCHEMBL2183746 | 0.81 | USP14 (0.35) | USP14PARP14 | |
| SCHEMBL2182322 | 0.81 | HSP90AA1 (0.41) | USP14 | |
| SCHEMBL2180311 | 0.80 | HSP90AA1 (0.37) | USP14 | |
| SCHEMBL2185932 | 0.79 | HSP90AA1 (0.36) | USP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265598-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | Sanofi-Aventis (FR) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |