Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.67 |
| ▸ | PPARG | P37231 | 7/20 | 0.67 |
| ▸ | PPARD | Q03181 | 7/20 | 0.67 |
| ▸ | PPARA | Q07869 | 7/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TLR2 | O60603 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | FABP4 | P15090 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.67 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentadecane SCHEMBL8773457 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Bicarbonate SCHEMBL11317868 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Bicarbonate SCHEMBL5273883 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Bicarbonate SCHEMBL7775132 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Tetradecane SCHEMBL4614838 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Undecane SCHEMBL9545965 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hexadecane SCHEMBL25216545 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octane SCHEMBL20576382 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Undecane SCHEMBL20678412 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Tridecane SCHEMBL165433 | 1.00 | GPR84 (0.67) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11197874-B2 | Use of an amphoteric chelating agent for preventing contact allergies | PREVOR INTERNATIONAL (FR) | 2021-12-14 | — | — | US | disclosed |
| US-20210275553-A1 | USE OF A CREAM THAT PROTECTS AGAINST THE EFFECTS OF AGGRESSIVE CHEMICAL AGENTS IN CONTACT WITH THE SKIN | PREVOR INTERNATIONAL (FR) | 2021-09-09 | — | — | US | disclosed |
| US-10953024-B2 | Use of a cream that protects against the effects of aggressive chemical agents in contact with the skin | PREVOR INTERNATIONAL (FR) | 2021-03-23 | — | — | US | disclosed |
| EP-2874661-B1 | USE OF A CREAM THAT PROTECTS AGAINST THE EFFECTS OF AGGRESSIVE CHEMICAL AGENTS IN CONTACT WITH THE SKIN | PREVOR INT (FR) | 2018-08-08 | — | — | EP | disclosed |
| EP-2874604-B1 | USE OF AN AMPHOTERIC CHELATING AGENT FOR PREVENTING CONTACT ALLERGIES | PREVOR INT (FR) | 2018-02-14 | — | — | EP | disclosed |
| US-9883991-B2 | Alkyl sulfosuccinate mixtures, and use thereof | COGNIS IP MANAGEMENT GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| US-20150202217-A1 | USE OF AN AMPHOTERIC CHELATING AGENT FOR PREVENTING CONTACT ALLERGIES | PREVOR INTERNATIONAL (FR) | 2015-07-23 | — | — | US | disclosed |
| US-20150190357-A1 | USE OF A CREAM THAT PROTECTS AGAINST THE EFFECTS OF AGGRESSIVE CHEMICAL AGENTS IN CONTACT WITH THE SKIN | PREVOR INTERNATIONAL (FR) | 2015-07-09 | — | — | US | disclosed |
| EP-2874604-A1 | USE OF AN AMPHOTERIC CHELATING AGENT FOR PREVENTING CONTACT ALLERGIES | PREVOR INTERNATIONAL (FR) | 2015-05-27 | — | — | EP | disclosed |
| EP-2874661-A1 | USE OF A CREAM THAT PROTECTS AGAINST THE EFFECTS OF AGGRESSIVE CHEMICAL AGENTS IN CONTACT WITH THE SKIN | PREVOR INTERNATIONAL (FR) | 2015-05-27 | — | — | EP | disclosed |
| EP-2349989-B1 | MIXTURES OF ALKYLSULFOSUCCINATES AND THEIR USE | COGNIS IP MAN GMBH (DE) | 2014-06-18 | — | — | EP | disclosed |
| WO-2014013195-A1 | USE OF AN AMPHOTERIC CHELATING AGENT FOR PREVENTING CONTACT ALLERGIES | PREVOR INTERNATIONAL (FR) | 2014-01-23 | — | — | WO | disclosed |
| WO-2014013194-A1 | USE OF A CREAM THAT PROTECTS AGAINST THE EFFECTS OF AGGRESSIVE CHEMICAL AGENTS IN CONTACT WITH THE SKIN | PREVOR INTERNATIONAL (FR) | 2014-01-23 | — | — | WO | disclosed |
| US-20120128601-A1 | Alkyl Sulfosuccinate Mixtures, And Use Thereof | COGNIS IP MANAGEMENT GMBH (DE) | 2012-05-24 | — | — | US | disclosed |
| EP-2179986-A1 | Mixtures of alkylsulfosuccinates and their use | Cognis IP Management GmbH (DE) | 2010-04-28 | — | — | EP | disclosed |
| EP-2116221-A1 | Cosmetic preparation containing hydrocarbons | Cognis IP Management GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |
| EP-2111847-A1 | Hydrocarbon mixtures and their use | Cognis IP Management GmbH (DE) | 2009-10-28 | — | — | EP | disclosed |
| EP-2014274-A1 | Hydrocarbon compounds and their use | Cognis IP Management GmbH (DE) | 2009-01-14 | — | — | EP | disclosed |
| US-20070269525-A1 | O/W Gel Compositions Comprising Wax | COGNIS IP MANAGEMENT GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| EP-1764080-A1 | Cosmetic oil bodies | Cognis IP Management GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120128601-A1 | Alkyl Sulfosuccinate Mixtures, And Use Thereof | ASS1, STS, ARSA | GPR84 1710/4885PPARG 1208/4885PPARD 1475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.