Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 3/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16974026 | 0.79 | TLR7 (0.54) | TLR8TLR7MPOKDRMEN1 | |
| SCHEMBL960548 | 0.73 | TLR7 (0.54) | TLR8TLR7MPOSLC9A1KDR | |
| SCHEMBL254046 | 0.73 | TLR8 (0.50) | TLR8TLR7MPOSLC9A1KDR | |
| SCHEMBL8633139 | 0.72 | TLR8 (0.47) | TLR8TLR7MPOKDRMEN1 | |
| SCHEMBL9229133 | 0.72 | TLR8 (0.49) | TLR8TLR7MPOSLC9A1KDR | |
| SCHEMBL29311541 | 0.72 | TLR8 (0.49) | TLR8TLR7MPOSLC9A1KDR | |
| SCHEMBL254210 | 0.71 | KDR (0.42) | TLR8TLR7MPOSLC9A1KDR | |
| SCHEMBL29720427 | 0.70 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL22806917 | 0.70 | TLR8 (0.72) | TLR8TLR7MPOMEN1CYP1A2 | |
| SCHEMBL29787346 | 0.70 | TLR8 (0.72) | TLR8TLR7MPOMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603917-B1 | IMMUNOMODULATING HETEROCYCLIC COMPOUNDS | MEDIGENE LTD (GB) | 2010-11-24 | — | — | EP | disclosed |