Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.72 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.72 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.41 |
| ▸ | MPO | P05164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22806917 | 1.00 | TLR8 (0.72) | TLR8TLR7SLC2A1MPOMEN1 | |
| SCHEMBL5506468 | 0.92 | TLR7 (0.60) | TLR8TLR7SLC2A1MEN1KMT2A | |
| SCHEMBL1233701 | 0.84 | TLR8 (1.00) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL29720427 | 0.84 | TLR8 (1.00) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL22445125 | 0.82 | TLR8 (0.50) | TLR8TLR7CYP1A2KDM4EALDH1A1 | |
| SCHEMBL17083434 | 0.78 | MAOA (0.46) | TLR8TLR7MEN1KMT2AKDM4E | |
| SCHEMBL5507108 | 0.76 | TLR7 (0.57) | TLR8TLR7SLC2A1MEN1KMT2A | |
| SCHEMBL1232530 | 0.75 | TLR7 (0.85) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL14323257 | 0.74 | ADORA3 (0.48) | TLR8TLR7CYP1A2KMT2AMAPT | |
| SCHEMBL5507105 | 0.74 | TLR8 (0.41) | TLR8TLR7SLC2A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114746420-A | 1- (4- (aminomethyl) benzyl) -2-butyl-2H-pyrazolo [3,4-c ] quinolin-4-amine derivatives as Toll-like receptor (TLR)7/8 agonists and related compounds and antibody drug conjugates thereof for cancer therapy and diagnosis | 苏特罗生物制药公司 | 2022-07-12 | — | — | CN | disclosed |