Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 7/20 | 0.37 |
| ▸ | CA12 | O43570 | 6/20 | 0.37 |
| ▸ | CA2 | P00918 | 6/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587233 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2587230 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL3417552 | 0.88 | ALDH1A1 (0.41) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2581531 | 0.88 | CA1 (0.42) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2581530 | 0.88 | CA1 (0.42) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2583188 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2583191 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2580582 | 0.82 | CA1 (0.42) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2580586 | 0.82 | CA1 (0.42) | ALDH1A1LMNATP53MAPTTDP1 | |
| SCHEMBL2585719 | 0.82 | LMNA (0.50) | ALDH1A1LMNATP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-B1 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET INC (US) | 2010-12-15 | — | — | EP | disclosed |