Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.69 |
| ▸ | CA1 | P00915 | 5/20 | 0.69 |
| ▸ | CA9 | Q16790 | 3/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | S100B | P04271 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417678 | 1.00 | CA2 (0.69) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL59999 | 0.94 | ALDH1A1 (0.63) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL60000 | 0.94 | ALDH1A1 (0.63) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL13084384 | 0.94 | ALDH1A1 (0.63) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL11585633 | 0.93 | CA2 (0.62) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL11585639 | 0.93 | CA2 (0.62) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL11585642 | 0.93 | CA2 (0.62) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL2451391 | 0.93 | CA2 (0.62) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL2451394 | 0.93 | CA2 (0.62) | CA2CA1CA9PTGS2CA12 | |
| SCHEMBL1374708 | 0.92 | ALDH1A1 (0.61) | CA2CA1CA9PTGS2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2014281-A1 | Use of inhibitors of sirtuins and/or ampk for the preparation of a medicament for the treatment of polyalanine diseases. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-01-14 | — | — | EP | claimed |
| WO-2008155390-A2 | USE OF INHIBITORS OF SIRTUINS AND/OR AMPK FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF POLYALANINE DISEASES. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-24 | — | — | WO | claimed |
| US-4268603-A | Photoresist compositions | TOKYO OHKA KOGYO KABUSHIKI KAISHA (JP) | 1981-05-19 | — | — | US | claimed |
| JP-62267185-A | — | — | None | — | — | JP | disclosed |
| US-20250326727-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | PENN STATE RES FOUND (US) | 2025-10-23 | — | — | US | disclosed |
| US-12304895-B2 | 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making | THE PENN STATE RESEARCH FOUNDATION UNIVERSITY (US) | 2025-05-20 | — | — | US | disclosed |
| US-20220213046-A1 | 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making | THE PENN STATE RESEARCH FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| WO-2020237063-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | THE PENN STATE RESEARCH FOUNDATION (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2010042868-A2 | METHODS FOR TREATING OBESITY | UNIVERSITY OF WASHINGTON (US) | 2010-04-15 | — | — | WO | disclosed |
| EP-2014281-A1 | Use of inhibitors of sirtuins and/or ampk for the preparation of a medicament for the treatment of polyalanine diseases. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008155390-A2 | USE OF INHIBITORS OF SIRTUINS AND/OR AMPK FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF POLYALANINE DISEASES. | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-24 | — | — | WO | disclosed |
| US-4066609-A | GLASS FABRIC OR FIBER | CIBA-GEIGY CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |
| US-4030930-A | PHOTOGRAPHY, SILVER HALIDES | FUJI PHOTO FILM CO., LTD. (JA) | 1977-06-21 | — | — | US | disclosed |
| US-4028129-A | CONTAINING AN INORGANIC PEROXIDE OR A PEROXODISULFATE TO INHIBIT FOGGING | FUJI PHOTO FILM CO., LTD. (JA) | 1977-06-07 | — | — | US | disclosed |
| US-4021250-A | PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JA) | 1977-05-03 | — | — | US | disclosed |
| US-3993630-A | Polyimide, polyamide-imide or polyamide-acids with olefin end groups in combination with a reactive Schiff base compound | CIBA-GEIGY CORPORATION (US) | 1976-11-23 | — | — | US | disclosed |
| US-3966678-A | Maleic anhydride-polyaldimine prepolymers | RHONE-POULENC S.A. (FR) | 1976-06-29 | — | — | US | disclosed |
| US-3960812-A | DIELECTRICS, MECHANICAL PROPERTIES | CIBA-GEIGY CORPORATION (US) | 1976-06-01 | — | — | US | disclosed |
| US-3944525-A | Crosslinked resins prepared from an N,N'-bis-imide and a schiff base | CIBA-GEIGY CORPORATION (US) | 1976-03-16 | — | — | US | disclosed |
| US-3933507-A | LIGHT INSENSITIVE SILVER SALT, POLYMETHINE SENSITIZER | AGFA-GEVAERT, A.G. (DT) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213046-A1 | 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making | CCNL2, TTL, ATXN2L | CA2 2193/4885CA1 4166/4885CA9 1962/4885 |
| US-12304895-B2 | 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making | CCNL2, TTL, ATXN2L | CA2 2193/4885CA1 4166/4885CA9 1962/4885 |
| US-20250326727-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | CCNL2, CDKL3, TTL | CA2 2183/4885CA1 4173/4885CA9 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.