Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.66 |
| ▸ | HTR3A | P46098 | 20/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.66 |
| ▸ | HRH2 | P25021 | 2/20 | 0.66 |
| ▸ | HTR1B | P28222 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 2/20 | 0.66 |
| ▸ | HRH1 | P35367 | 2/20 | 0.66 |
| ▸ | HTR5A | P47898 | 2/20 | 0.66 |
| ▸ | HTR6 | P50406 | 2/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418908 | 0.91 | HTR1A (0.66) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3422164 | 0.90 | HTR1A (0.64) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3418895 | 0.86 | HTR1A (0.58) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3421737 | 0.86 | HTR1A (0.62) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3421826 | 0.86 | HTR1A (0.65) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3416172 | 0.85 | HTR1A (0.65) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3416625 | 0.85 | HTR1A (0.59) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3421766 | 0.83 | HTR1A (0.64) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23010851 | 0.82 | HTR1A (0.50) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3418573 | 0.81 | HTR1A (0.64) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | claimed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | claimed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | claimed |
| US-7678800-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence | H. LUNDBECK A/S (DK) | 2010-03-16 | — | — | US | disclosed |
| EP-1771415-B1 | 2- (1H-INDOLYLSULFANYL) -ARYL AMINE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIVE DISORDERS, PAIN, ADHD AND STRESS URINARY INCONTINENCE | LUNDBECK & CO AS H (DK) | 2009-01-07 | — | — | EP | disclosed |
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027074-A1 | 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence | SLC6A2, HTR2C, SLC6A3 | HTR1A 22/4885HTR3A 9/4885CYP1A2 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.