Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112098 | 0.86 | REN (0.78) | RENKCNH2CYP3A4 | |
| SCHEMBL3112119 | 0.86 | REN (0.78) | RENKCNH2CYP3A4 | |
| SCHEMBL3418495 | 0.84 | REN (0.75) | RENKCNH2CYP3A4 | |
| SCHEMBL3108124 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3108094 | 0.83 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3107698 | 0.81 | REN (0.76) | RENKCNH2CYP3A4 | |
| SCHEMBL3109779 | 0.81 | REN (0.76) | RENKCNH2CYP3A4 | |
| SCHEMBL3105660 | 0.80 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3105676 | 0.80 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL3107683 | 0.80 | REN (1.00) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229363-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | claimed |
| WO-2009070869-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | claimed |
| EP-2229363-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070869-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |