Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29164888 | 0.74 | TYK2 (0.42) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL27489096 | 0.73 | NPC1 (0.58) | NAMPTKDM4EALDH1A1MEN1NPC1 | |
| SCHEMBL696231 | 0.73 | NPC1 (0.56) | MAPTALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL2803397 | 0.72 | SMN1; SMN2 (0.46) | NAMPTKDM4EMAPTALDH1A1THRB | |
| SCHEMBL7164136 | 0.72 | RAB9A (0.53) | NAMPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL3064600 | 0.71 | — | — | |
| SCHEMBL5234703 | 0.70 | HCAR3 (0.57) | NAMPTKDM4EMAPTALDH1A1THRB | |
| SCHEMBL8819957 | 0.70 | RAB9A (0.70) | NAMPTKDM4EMAPTALDH1A1THRB | |
| SCHEMBL12225791 | 0.70 | SMN1; SMN2 (0.68) | NAMPTKDM4EMAPTALDH1A1THRB | |
| SCHEMBL11908920 | 0.70 | KDM4E (0.62) | NAMPTKDM4EMAPTALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |