Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27869504 | 0.92 | ALDH1A1 (0.44) | KDM4EMAPTHTR1BPDE5APDE4D | |
| SCHEMBL27639454 | 0.87 | HTR7 (0.44) | HTR7KDM4EMAPTHTR1BDRD2 | |
| SCHEMBL188778 | 0.83 | KDM4E (0.53) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL161592 | 0.81 | CSNK2A1 (0.47) | KDM4EMAPTPDE7AALDH1A1GAA | |
| SCHEMBL2479633 | 0.80 | HTR7 (0.53) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL4577229 | 0.80 | HTR7 (0.53) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL27991741 | 0.80 | ESR1 (0.44) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL16240198 | 0.80 | HTR7 (0.60) | HTR7KDM4EHTR1BDRD2DRD1 | |
| SCHEMBL27852671 | 0.80 | KDM4E (0.50) | KDM4EMAPTHTR1BALDH1A1TDP1 | |
| SCHEMBL160991 | 0.79 | SMN1; SMN2 (0.45) | MAPTALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231625-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |