Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rebamipide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.87 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.49 |
| ▸ | ITGAL | P20701 | 5/20 | 0.49 |
| ▸ | F11 | P03951 | 3/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rebamipide SCHEMBL23346201 | 0.93 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL5794018 | 0.93 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL29560992 | 0.93 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL221527 | 0.93 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL21623658 | 0.93 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL9114879 | 0.92 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL28798513 | 0.92 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL27819911 | 0.92 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL2292009 | 0.92 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL28341360 | 0.92 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706383-B1 | Amine salt of carbostyril derivative useful for the treatment of, inter alia, gastric ulcer | OTSUKA PHARMA CO LTD (JP) | 2015-07-22 | — | — | EP | disclosed |
| EP-2253619-A1 | Amine salt of carbostyril derivative | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |