SCHEMBL3421071

SCHEMBL3421071

NC(=O)c1cccc(Cl)c1-c1cc[nH]n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 4/20 0.40
KDM4E B2RXH2 3/20 0.38
ALDH1A1 P00352 3/20 0.38
TSHR P16473 2/20 0.38
LMNA P02545 1/20 0.38
AURKA O14965 2/20 0.38
KEAP1 Q14145 1/20 0.37
NFE2L2 Q16236 1/20 0.37
PDPK1 O15530 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
PKM P14618 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KMT2A Q03164 3/20 0.36
ATM Q13315 1/20 0.36
PLK4 O00444 1/20 0.36
CHEK1 O14757 1/20 0.36
DAPK3 O43293 1/20 0.36
MAP4K4 O95819 1/20 0.36
CSF1R P07333 1/20 0.36
RET P07949 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3422877 0.83 PARP1 (0.41) PARP1KDM4EALDH1A1LMNAAURKA
SCHEMBL7163549 0.82 PARP1 (0.40) PARP1AURKAKEAP1NFE2L2PDPK1
SCHEMBL11624658 0.80 IDO1 (0.35) TSHRLMNASMN1; SMN2CHEK1RET
SCHEMBL3419413 0.79 PARP1 (0.44) PARP1AURKAKEAP1NFE2L2SMN1; SMN2
SCHEMBL3418979 0.79 BCAT2 (0.41) PARP1KDM4EALDH1A1LMNAAURKA
SCHEMBL3421682 0.78 CDC7 (0.38) PARP1AURKAKEAP1NFE2L2PDPK1
SCHEMBL29629416 0.78 PARP1 (0.43) PARP1LMNAAURKAKEAP1NFE2L2
SCHEMBL31005224 0.76 HSP90AA1 (0.45) ALDH1A1TSHRLMNAAURKASMN1; SMN2
SCHEMBL696661 0.74 BCAT2 (0.55) PARP1KDM4EALDH1A1TSHRKEAP1
SCHEMBL30528244 0.74 BCAT2 (0.55) PARP1KDM4EALDH1A1TSHRKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4555547-B2 2010-10-06 JP claimed
JP-2004505977-A 2004-02-26 JP claimed
EP-1320531-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-06-25 EP claimed
WO-2002012242-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2002-02-14 WO claimed
EP-1320531-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-06-25 EP disclosed
WO-2002012242-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2002-02-14 WO disclosed