SCHEMBL3422965

SCHEMBL3422965

C=C(Cc1ccc(CC(=C)C(=O)O)c2ccccc12)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CYP1A2 P05177 1/20 0.39
HMGB1 P09429 1/20 0.38
CXCL12 P48061 1/20 0.38
HTR6 P50406 1/20 0.38
AKR1B1 P15121 2/20 0.38
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3423766 0.92 TDP1 (0.50) TDP1ALDH1A1MAPTKDM4EMEN1
SCHEMBL31604997 0.91 IDO1 (0.45) TDP1ALDH1A1MAPTKDM4EMEN1
SCHEMBL2192625 0.91 IDO1 (0.45) TDP1ALDH1A1MAPTKDM4EMEN1
SCHEMBL819647 0.85 TDP1 (0.68) TDP1MAPTKDM4EMEN1HPGD
SCHEMBL8746636 0.85 AKR1B1 (0.46) TDP1ALDH1A1MAPTKDM4EMEN1
SCHEMBL26180948 0.83 TDP1 (0.56) TDP1ALDH1A1KDM4EMEN1HPGD
SCHEMBL16660495 0.82 CYP2C9 (0.40) TDP1ALDH1A1KDM4EMEN1KMT2A
SCHEMBL3426377 0.81 KDM4E (0.49) TDP1ALDH1A1MAPTKDM4EMEN1
SCHEMBL3422957 0.79 TDP1 (0.40) TDP1KDM4EMEN1HPGDKMT2A
SCHEMBL11467086 0.79 AKR1B1 (0.42) TDP1ALDH1A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1840652-A1 Photo-curable resins and resin compositions with very high refractive indices for application in plastic optics SeeReal Technologies S.A. (LU) 2007-10-03 EP claimed
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP claimed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP claimed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US claimed
US-8080603-B2 Low hysteresis rubber elastomer MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2011-12-20 US disclosed
US-20100056686-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2010-03-04 US disclosed
US-20100012241-A1 CUSHION GUM MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2010-01-21 US disclosed
EP-2114696-A1 LOW HYSTERESIS RUBBER ELASTOMER Societe de Technologie Michelin (FR) 2009-11-11 EP disclosed
WO-2008079107-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2008-07-03 WO disclosed
WO-2007110387-A1 PHOTO-CURABLE RESINS AND RESIN COMPOSITIONS WITH VERY HIGH REFRACTIVE INDICES FOR APPLICATION IN PLASIC OPTICS SEEREAL TECHNOLOGIES S.A. (DE) 2007-10-04 WO disclosed
EP-1840652-A1 Photo-curable resins and resin compositions with very high refractive indices for application in plastic optics SeeReal Technologies S.A. (LU) 2007-10-03 EP disclosed
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP disclosed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP disclosed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US disclosed