SCHEMBL3423124

SCHEMBL3423124

C=C(Cc1cccc2cccc(CC(=C)C(=O)O)c12)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.43
KMT2A Q03164 5/20 0.40
MEN1 O00255 4/20 0.40
PPARG P37231 1/20 0.40
HSD17B10 Q99714 3/20 0.37
KDM4E B2RXH2 4/20 0.37
CYP1A2 P05177 3/20 0.37
HPGD P15428 3/20 0.37
ALDH1A1 P00352 2/20 0.37
GLA P06280 1/20 0.37
POLB P06746 1/20 0.37
CYP2D6 P10635 1/20 0.37
AKR1B1 P15121 2/20 0.35
CTBP2 P56545 2/20 0.35
MAPT P10636 2/20 0.35
ALOX15 P16050 1/20 0.35
ATM Q13315 1/20 0.34
CTNNB1 P35222 1/20 0.33
LMNA P02545 1/20 0.33
PTGER4 P35408 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5047216 0.82 KMT2A (0.58) TDP1KMT2AMEN1PPARGHSD17B10
SCHEMBL819647 0.81 TDP1 (0.68) TDP1KMT2AMEN1KDM4ECYP1A2
SCHEMBL8746636 0.81 AKR1B1 (0.46) TDP1KMT2AMEN1KDM4ECYP1A2
SCHEMBL3423766 0.80 TDP1 (0.50) TDP1KMT2AMEN1KDM4ECYP1A2
SCHEMBL3422226 0.80 AKR1B1 (0.38) TDP1KDM4ECYP1A2ALDH1A1POLB
SCHEMBL21617918 0.79 TDP1 (0.64) TDP1KMT2AMEN1PPARGHSD17B10
SCHEMBL3423595 0.78 MEN1 (0.41) TDP1KMT2AMEN1PPARGKDM4E
SCHEMBL2243225 0.78 TDP1 (0.49) TDP1KMT2AMEN1HSD17B10KDM4E
SCHEMBL26180948 0.76 TDP1 (0.56) TDP1KMT2AMEN1HSD17B10KDM4E
SCHEMBL11467086 0.76 AKR1B1 (0.42) TDP1KMT2AMEN1ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP claimed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP claimed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US claimed
US-8080603-B2 Low hysteresis rubber elastomer MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2011-12-20 US disclosed
US-20100056686-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2010-03-04 US disclosed
US-20100012241-A1 CUSHION GUM MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2010-01-21 US disclosed
EP-2114696-A1 LOW HYSTERESIS RUBBER ELASTOMER Societe de Technologie Michelin (FR) 2009-11-11 EP disclosed
WO-2008079726-A1 CUSHION GUM SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2008-07-03 WO disclosed
WO-2008079107-A1 LOW HYSTERESIS RUBBER ELASTOMER SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2008-07-03 WO disclosed
EP-0644232-B1 Free radical cured rubber GOODYEAR TIRE & RUBBER (US) 1997-03-05 EP disclosed
EP-0644232-A1 Free radical cured rubber THE GOODYEAR TIRE & RUBBER COMPANY (US) 1995-03-22 EP disclosed
US-5310811-A Abrasion resistance THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-05-10 US disclosed