Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.57 |
| ▸ | TUBB | P07437 | 4/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | TNKS | O95271 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037555 | 0.85 | TUBB4A (0.56) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30062569 | 0.82 | TUBB4A (0.55) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31463101 | 0.82 | TYMS (0.72) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL578430 | 0.82 | TUBB4A (0.55) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL26017629 | 0.82 | KDM4E (0.56) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4725175 | 0.82 | TUBB4A (0.55) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5313776 | 0.82 | TYMS (0.72) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12693599 | 0.82 | KDM4E (0.42) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3424900 | 0.82 | TUBB4A (0.55) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13343598 | 0.80 | KDM4E (0.57) | KDM4ETUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608317-A4 | DIPEPTIDYL PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2006-12-27 | — | — | EP | claimed |
| EP-1608317-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | Takeda San Diego, Inc. (US) | 2005-12-28 | — | — | EP | claimed |
| US-20050004117-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004087053-A9 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX INC (US) | 2004-11-11 | — | — | WO | claimed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | claimed |
| WO-2024026424-A1 | QUINAZOLINONE DERIVATIVES AS AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2020-09-24 | — | — | US | disclosed |
| EP-3694840-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | Hoffmann-La Roche AG (CH) | 2020-08-19 | — | — | EP | disclosed |
| CN-111247129-A | Piperazine derivatives as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2020-06-05 | — | — | CN | disclosed |
| WO-2019072785-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-04-18 | — | — | WO | disclosed |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040242566-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | SYRRX, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004087053-A9 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX INC (US) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004087053-A9 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX INC (US) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087053-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS | SYRRX, INC. (US) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004117-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | KDM4E 2328/4885TUBB4A 4561/4885TUBB 4758/4885 |
| US-20040242566-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP3, DPP4 | KDM4E 2254/4885TUBB4A 4764/4885TUBB 4755/4885 |
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | KDM4E 2009/4885TUBB4A 2062/4885TUBB 1660/4885 |
| US-20040242568-A1 | Dipeptidyl peptidase inhibitors | DPP9, DPP4, DPP3 | KDM4E 2122/4885TUBB4A 4610/4885TUBB 4722/4885 |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | MAGI3, PYM1, MAG | KDM4E 2009/4885TUBB4A 2062/4885TUBB 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.