Sugi Predict

Sugi Predict / Compounds / SCHEMBL3037555

SCHEMBL3037555

SCHEMBL3037555

O=c1[nH]c(Cl)nc2cc(Cl)ccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 1/20 0.56
▸ TUBB P07437 1/20 0.56
▸ TUBA3C P0DPH7 1/20 0.56
▸ TUBA1B P68363 1/20 0.56
▸ TUBA4A P68366 1/20 0.56
▸ TUBB4B P68371 1/20 0.56
▸ TUBB3 Q13509 1/20 0.56
▸ TUBB2A Q13885 1/20 0.56
▸ TUBB8 Q3ZCM7 1/20 0.56
▸ TUBA3E Q6PEY2 1/20 0.56
▸ TUBA1A Q71U36 1/20 0.56
▸ TUBA1C Q9BQE3 1/20 0.56
▸ TUBB6 Q9BUF5 1/20 0.56
▸ TUBB2B Q9BVA1 1/20 0.56
▸ TUBB1 Q9H4B7 1/20 0.56
▸ ALDH1A1 P00352 1/20 0.54
▸ KMT2A Q03164 3/20 0.51
▸ MAPT P10636 3/20 0.51
▸ HPGD P15428 2/20 0.51
▸ MEN1 O00255 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3423481 0.85 KDM4E (0.59) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23333473 0.82 PARP1 (0.51) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL578054 0.82 PARP14 (0.46) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30012731 0.82 NPC1 (0.44) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21089737 0.82 NPC1 (0.44) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL26017734 0.82 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL6670119 0.82 TYMS (0.63) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL6929589 0.80 KDM4E (0.65) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29900514 0.80 KDM4E (0.65) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13343606 0.78 KDM4E (0.59) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050004117-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2005-01-06 — — US claimed
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-11-27 — — US disclosed
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-12-05 — — US disclosed
EP-4445902-A2 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2024-10-16 — — EP disclosed
EP-4081305-B1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS CARNA BIOSCIENCES INC (JP) 2024-09-18 — — EP disclosed
US-12054490-B2 Diacylglycerol kinase modulating compounds GILEAD SCIENCES, INC. (US) 2024-08-06 — — US disclosed
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 — — CN disclosed
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-06 — — US disclosed
CN-115362003-B Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-03-22 — — CN disclosed
CN-117736207-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-03-22 — — CN disclosed
EP-1608317-A2 DIPEPTIDYL PEPTIDASE INHIBITORS Takeda San Diego, Inc. (US) 2005-12-28 — — EP disclosed
US-20050004117-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2005-01-06 — — US disclosed
US-20040259870-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2004-12-23 — — US disclosed
US-20040242568-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2004-12-02 — — US disclosed
US-20040242568-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2004-12-02 — — US disclosed
US-20040242566-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2004-12-02 — — US disclosed
US-20040242568-A1 Dipeptidyl peptidase inhibitors SYRRX, INC. 2004-12-02 — — US disclosed
WO-2004087053-A9 DIPEPTIDYL PEPTIDASE INHIBITORS SYRRX INC (US) 2004-11-11 — — WO disclosed
WO-2004087053-A2 DIPEPTIDYL PEPTIDASE INHIBITORS SYRRX, INC. (US) 2004-10-14 — — WO disclosed
WO-2004087053-A2 DIPEPTIDYL PEPTIDASE INHIBITORS SYRRX, INC. (US) 2004-10-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050004117-A1 Dipeptidyl peptidase inhibitors DPP9, DPP4, DPP3 TUBB4A 4561/4885TUBB 4758/4885TUBA3C 3796/4885
US-20240400568-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK TUBB4A 3024/4885TUBB 2817/4885TUBA3C 4229/4885
US-20040242566-A1 Dipeptidyl peptidase inhibitors DPP9, DPP3, DPP4 TUBB4A 4764/4885TUBB 4755/4885TUBA3C 3985/4885
US-12054490-B2 Diacylglycerol kinase modulating compounds DGKG, DGKB, DGKK TUBB4A 3024/4885TUBB 2817/4885TUBA3C 4229/4885
US-20040242568-A1 Dipeptidyl peptidase inhibitors DPP9, DPP4, DPP3 TUBB4A 4610/4885TUBB 4722/4885TUBA3C 3597/4885
US-20040259870-A1 Dipeptidyl peptidase inhibitors DPP9, DPP4, DPP3 TUBB4A 4531/4885TUBB 4687/4885TUBA3C 3486/4885
US-20240182476-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK TUBB4A 3024/4885TUBB 2817/4885TUBA3C 4229/4885
US-20250361236-A9 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS DGKG, DGKB, DGKK TUBB4A 3024/4885TUBB 2817/4885TUBA3C 4229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.