SCHEMBL3424322

SCHEMBL3424322

CC(C(=O)Nc1cc[nH]n1)C(=O)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.48
CCNA2 P20248 6/20 0.41
CDK2 P24941 6/20 0.41
CCNA1 P78396 6/20 0.41
POLB P06746 1/20 0.40
ADORA2A P29274 3/20 0.38
ADORA1 P30542 3/20 0.38
ADORA3 P0DMS8 2/20 0.38
RAB9A P51151 2/20 0.38
HSP90AA1 P07900 2/20 0.38
ATM Q13315 2/20 0.38
NPC1 O15118 1/20 0.38
GAA P10253 1/20 0.38
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ELOVL1 Q9BW60 2/20 0.36
ADORA2B P29275 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1259717 0.82 POLB (0.60) KMT2ACCNA2CDK2CCNA1POLB
SCHEMBL3423922 0.78 ALDH1A1 (0.42) KMT2AADORA2AADORA1ADORA3RAB9A
SCHEMBL696662 0.77 KMT2A (0.58) KMT2ACCNA2CDK2CCNA1ADORA2A
SCHEMBL7281510 0.75 XIAP (0.51) CCNA2CDK2CCNA1
SCHEMBL1086017 0.75 GAA (0.64) KMT2APOLBRAB9AHSP90AA1ATM
SCHEMBL5799936 0.71 PSEN1 (0.50) KMT2ACCNA2CDK2CCNA1POLB
SCHEMBL3064600 0.70
SCHEMBL1397470 0.70 KMT2A (0.58) KMT2APOLBRAB9AATMNPC1
Acetic Acid SCHEMBL2955582 0.70 KDM4E (0.43) ADORA2AADORA1ADORA3RAB9AHSP90AA1
SCHEMBL10506544 0.70 KMT2A (0.60) KMT2APOLBRAB9AHSP90AA1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4555547-B2 2010-10-06 JP claimed
JP-2004505977-A 2004-02-26 JP claimed
EP-1320531-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-06-25 EP claimed
WO-2002012242-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2002-02-14 WO claimed
EP-1320531-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Pharmacia Italia S.p.A. (IT) 2003-06-25 EP disclosed
WO-2002012242-A2 BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PHARMACIA ITALIA S.P.A. (IT) 2002-02-14 WO disclosed