Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.69 |
| ▸ | HCK | P08631 | 2/20 | 0.67 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.67 |
| ▸ | BTK | Q06187 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 5/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788636 | 0.91 | EPHB2 (0.59) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL4788638 | 0.91 | CSF1R (0.69) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL30339882 | 0.89 | MAPK14 (0.66) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL24070473 | 0.89 | MAPK14 (0.66) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL3424818 | 0.87 | MAPK14 (0.62) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL28382296 | 0.85 | EPHB2 (0.77) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL30546751 | 0.85 | EPHB2 (0.77) | ABL1EPHB2HCKNR2C2BTK | |
| SCHEMBL14953321 | 0.85 | ABL1 (0.78) | ABL1MAPK14MAP3K20MAP3K7MAP4K2 | |
| SCHEMBL29514885 | 0.85 | ABL1 (0.78) | ABL1MAPK14MAP3K20MAP3K7MAP4K2 | |
| SCHEMBL24070682 | 0.85 | MAPK14 (0.69) | ABL1EPHB2HCKNR2C2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |