SCHEMBL3424910

SCHEMBL3424910

COc1ccc2c(c1)CN(C(=O)OCc1ccccc1)CCS2

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RYR2 Q92736 18/20 0.70
KCNH2 Q12809 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31532645 1.00 RYR2 (0.70) RYR2KCNH2
SCHEMBL3430378 0.93 RYR2 (0.70) RYR2KCNH2
SCHEMBL3426026 0.92 RYR2 (0.58) RYR2KCNH2
SCHEMBL3426977 0.87 RYR2 (0.53) RYR2
SCHEMBL3427198 0.87 RYR2 (0.53) RYR2KCNH2
SCHEMBL6885187 0.85 RYR2 (0.67) RYR2KCNH2
SCHEMBL13694432 0.85 RYR2 (0.50) RYR2
SCHEMBL3427846 0.84 RYR2 (0.50) RYR2
SCHEMBL7991640 0.84 RYR2 (0.49) RYR2
SCHEMBL3428542 0.83 RYR2 (0.77) RYR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250302847-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYCARMA THERAPEUTICS, INC. 2025-10-02 US disclosed
US-20250170144-A1 CRYSTALLINE FORMS OF A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYCARMA THERAPEUTICS, INC. 2025-05-29 US disclosed
US-12161650-B2 Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof ARMGO PHARMA, INC. (US) 2024-12-10 US disclosed
EP-4433062-A1 THERAPEUTIC COMPOUNDS Armgo Pharma, Inc. (US) 2024-09-25 EP disclosed
US-12076326-B2 Crystalline forms of a ryanodine receptor modulator and uses thereof ARMGO PHARMA, INC. (US) 2024-09-03 US disclosed
US-12076327-B2 Crystalline forms of a ryanodine receptor modulator and uses thereof ARMGO PHARMA, INC. (US) 2024-09-03 US disclosed
US-12059426-B2 Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof ARMGO PHARMA, INC. (US) 2024-08-13 US disclosed
EP-4340861-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF Armgo Pharma, Inc. (US) 2024-03-27 EP disclosed
US-20230372358-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYCARMA THERAPEUTICS, INC. 2023-11-23 US disclosed
US-20230372358-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYCARMA THERAPEUTICS, INC. 2023-11-23 US disclosed
US-20130281512-A1 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2013-10-24 US disclosed
EP-2653466-A1 Agents for treating disorders involving modulation of ryanodine receptors Les Laboratoires Servier (FR) 2013-10-23 EP disclosed
EP-2653466-A1 Agents for treating disorders involving modulation of ryanodine receptors Les Laboratoires Servier (FR) 2013-10-23 EP disclosed
EP-2250159-B1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES ARMGO PHARMA INC (US) 2011-12-07 EP disclosed
EP-2250159-B1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES ARMGO PHARMA INC (US) 2011-12-07 EP disclosed
EP-2250159-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES Armgo Pharma, Inc. (US) 2010-11-17 EP disclosed
WO-2009111463-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES ARMGO PHARMA, INC. (US) 2009-09-11 WO disclosed
US-20090227788-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES RYCARMA THERAPEUTICS, INC. 2009-09-10 US disclosed
US-20090227788-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES RYCARMA THERAPEUTICS, INC. 2009-09-10 US disclosed
US-20090227788-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES RYCARMA THERAPEUTICS, INC. 2009-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302847-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYR1, RYR2, MUSK RYR2 2/4885KCNH2 1132/4885
US-12076326-B2 Crystalline forms of a ryanodine receptor modulator and uses thereof RYR1, RYR2, ATP2A1 RYR2 2/4885KCNH2 1249/4885
US-12076327-B2 Crystalline forms of a ryanodine receptor modulator and uses thereof RYR1, RYR2, ATP2A1 RYR2 2/4885KCNH2 1249/4885
US-20090227788-A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES TPMT, SULT2A1, KCNJ2 RYR2 547/4885KCNH2 103/4885
US-12059426-B2 Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof RYR1, RYR2, MUSK RYR2 2/4885KCNH2 1132/4885
US-12161650-B2 Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof RYR1, RYR2, MUSK RYR2 2/4885KCNH2 1132/4885
US-20130281512-A1 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS RYR1, RYR2, ATP2A1 RYR2 2/4885KCNH2 233/4885
US-20250170144-A1 CRYSTALLINE FORMS OF A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYR1, RYR2, ATP2A1 RYR2 2/4885KCNH2 1249/4885
US-20230372358-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A RYANODINE RECEPTOR MODULATOR AND USES THEREOF RYR1, RYR2, MUSK RYR2 2/4885KCNH2 1132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.