Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 11/20 | 0.54 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.44 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839442 | 0.89 | TP53 (0.46) | TP53FSCN1MAPTSLC2A1SLC2A2 | |
| SCHEMBL839657 | 0.89 | SLC2A1 (0.54) | TP53FSCN1MAPTSLC2A1SLC2A2 | |
| SCHEMBL838678 | 0.86 | TP53 (0.44) | TP53FSCN1MAPTSLC2A1SLC2A2 | |
| SCHEMBL839711 | 0.83 | SLC2A1 (0.47) | TP53FSCN1MAPTSLC2A1SLC2A2 | |
| SCHEMBL838336 | 0.81 | TP53 (0.41) | TP53MAPTSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL838829 | 0.80 | P2RX7 (0.46) | TP53MAPTRAB9ALMNANPC1 | |
| SCHEMBL839210 | 0.80 | GCK (0.47) | TP53MAPTSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL838694 | 0.78 | CYP17A1 (0.46) | TP53MAPTRAB9ALMNAGSK3B | |
| SCHEMBL839601 | 0.78 | RAB9A (0.55) | TP53MAPTRAB9ALMNANPC1 | |
| SCHEMBL838498 | 0.78 | RAB9A (0.46) | TP53MAPTRAB9ALMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247596-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | Natco Pharma Limited (IN) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098715-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-08-13 | — | — | WO | disclosed |