Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478739 | 0.87 | SLC2A1 (0.47) | SLC2A1BRD4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13754687 | 0.86 | HPGDS (0.43) | SLC2A1DGAT1HSD17B10HPGDSKDM4E | |
| SCHEMBL4475363 | 0.85 | NPC1 (0.40) | SLC2A1 | |
| SCHEMBL4481800 | 0.82 | RXFP1 (0.45) | SLC2A1BRD4DGAT1ALDH1A1HPGD | |
| SCHEMBL3392235 | 0.81 | KDM1A (0.39) | SLC2A1DGAT1SMN1; SMN2 | |
| SCHEMBL4565033 | 0.81 | SLC2A1 (0.43) | SLC2A1DGAT1KDM4E | |
| SCHEMBL4483589 | 0.81 | SLC2A1 (0.34) | SLC2A1DGAT1 | |
| SCHEMBL4490539 | 0.79 | KDM1A (0.41) | SLC2A1SMN1; SMN2 | |
| SCHEMBL4490712 | 0.79 | SLC2A1 (0.40) | SLC2A1DGAT1 | |
| Hydrochloric Acid SCHEMBL4489660 | 0.78 | DGAT1 (0.39) | SLC2A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |