Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 20/20 | 0.46 |
| ▸ | AURKA | O14965 | 19/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 13/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342651 | 1.00 | CDK1 (0.46) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL342942 | 0.87 | CDK1 (0.39) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL342943 | 0.87 | CDK1 (0.39) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL15428704 | 0.85 | CDK1 (0.48) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL15428705 | 0.85 | CDK1 (0.48) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL10167410 | 0.84 | AURKA (0.52) | CDK1AURKACCNB1AURKBCYP3A4 | |
| SCHEMBL342357 | 0.84 | AURKA (0.52) | CDK1AURKACCNB1AURKBCYP3A4 | |
| SCHEMBL342652 | 0.82 | CDK1 (0.48) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL343811 | 0.82 | AURKA (0.51) | CDK1AURKACCNB1AURKBCDK2 | |
| SCHEMBL10167379 | 0.81 | CDK1 (0.44) | CDK1AURKACCNB1AURKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | CDK1 10/4885AURKA 784/4885CCNB1 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.