Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 19/20 | 0.52 |
| ▸ | CDK1 | P06493 | 19/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 15/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167410 | 1.00 | AURKA (0.52) | AURKACDK1CCNB1AURKBCYP3A4 | |
| SCHEMBL343811 | 0.89 | AURKA (0.51) | AURKACDK1CCNB1AURKBCYP3A4 | |
| SCHEMBL15428705 | 0.88 | CDK1 (0.48) | AURKACDK1CCNB1AURKB | |
| SCHEMBL15428704 | 0.88 | CDK1 (0.48) | AURKACDK1CCNB1AURKB | |
| SCHEMBL343044 | 0.85 | MERTK (0.42) | AURKACDK1CCNB1AURKBBTK | |
| SCHEMBL343043 | 0.85 | MERTK (0.42) | AURKACDK1CCNB1AURKBBTK | |
| SCHEMBL342651 | 0.84 | CDK1 (0.46) | AURKACDK1CCNB1AURKBCYP3A4 | |
| SCHEMBL342650 | 0.84 | CDK1 (0.46) | AURKACDK1CCNB1AURKBCYP3A4 | |
| SCHEMBL10167379 | 0.84 | CDK1 (0.44) | AURKACDK1CCNB1AURKB | |
| SCHEMBL343351 | 0.84 | CDK1 (0.44) | AURKACDK1CCNB1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | claimed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | claimed |
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | AURKA 784/4885CDK1 10/4885CCNB1 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.