Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432959 | 0.88 | AGXT (0.38) | AGXTMRGPRX4IDO1FFAR1NOS3 | |
| SCHEMBL3426968 | 0.85 | AGXT (0.36) | AGXTMRGPRX4IDO1FFAR1NOS3 | |
| SCHEMBL4783563 | 0.82 | PRKCI (0.49) | AGXTF2 | |
| SCHEMBL4727676 | 0.82 | CYP4F2 (0.44) | AGXTIDO1F2 | |
| SCHEMBL3398564 | 0.80 | CHRM3 (0.41) | MRGPRX4FFAR1SHMT1SHMT2 | |
| SCHEMBL3431287 | 0.79 | MAP4K4 (0.49) | AGXTHSD17B1HSD17B2F2 | |
| SCHEMBL3428339 | 0.79 | IDO1 (0.38) | AGXTIDO1FFAR1F2 | |
| SCHEMBL12053389 | 0.79 | IDO1 (0.41) | AGXTIDO1FFAR1NOS3NOS1 | |
| SCHEMBL1362409 | 0.78 | LMNA (0.41) | MRGPRX4FFAR1SHMT1SHMT2 | |
| SCHEMBL12053392 | 0.77 | HDAC1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247184-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009100167-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |