Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.46 |
| ▸ | TACR3 | P29371 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429277 | 0.88 | TACR3 (0.43) | P2RX7TACR3 | |
| SCHEMBL928488 | 0.87 | P2RX7 (0.46) | P2RX7TACR3GRM5 | |
| SCHEMBL930058 | 0.87 | ALDH1A1 (0.45) | P2RX7TACR3ALDH1A1TDP1GAA | |
| SCHEMBL3426799 | 0.86 | TACR3 (0.43) | TACR3GRM5 | |
| SCHEMBL928836 | 0.84 | P2RX7 (0.62) | P2RX7TACR3GRM5 | |
| SCHEMBL930145 | 0.84 | P2RX7 (0.55) | P2RX7TACR3ALDH1A1TDP1GAA | |
| SCHEMBL930132 | 0.83 | ALDH1A1 (0.48) | TACR3ALDH1A1TDP1GAAMAPT | |
| SCHEMBL928665 | 0.83 | GRM5 (0.44) | P2RX7TACR3GRM5 | |
| SCHEMBL4191663 | 0.81 | P2RX7 (0.41) | P2RX7TACR3 | |
| SCHEMBL928807 | 0.80 | ALDH1A1 (0.48) | TACR3ALDH1A1TDP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247590-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | Merz Pharma GmbH & Co. KGaA (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009095254-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |