Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.35 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248483 | 0.94 | GPR119 (0.44) | GPR119HSP90AA1HSP90B1SGMS1SGMS2 | |
| SCHEMBL3405712 | 0.84 | HSP90AA1 (0.41) | GPR119HSP90AA1HSP90B1 | |
| SCHEMBL2243447 | 0.83 | GPR119 (0.52) | GPR119 | |
| SCHEMBL2253391 | 0.82 | GPR119 (0.43) | GPR119 | |
| SCHEMBL2250016 | 0.81 | GPR119 (0.42) | GPR119HSP90AA1 | |
| SCHEMBL2248264 | 0.80 | GPR119 (0.42) | GPR119HSP90AA1SGMS1SGMS2 | |
| SCHEMBL2248670 | 0.78 | ITGB3 (0.36) | HSP90AA1HSP90B1 | |
| SCHEMBL12356460 | 0.76 | GPR119 (0.42) | GPR119 | |
| SCHEMBL3184555 | 0.75 | GPR119 (0.55) | GPR119 | |
| SCHEMBL2249934 | 0.74 | GPR119 (0.43) | GPR119HSP90AA1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |