Benzamidine

Benzamidine

SCHEMBL3427811

N=C(N)c1ccccc1.NCCc1ccc(S(=O)(=O)F)cc1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 6/20 0.66
TMPRSS4 Q9NRS4 2/20 0.66
TP53 P04637 1/20 0.66
CYP1A2 P05177 1/20 0.66
CYP2D6 P10635 1/20 0.66
TSHR P16473 1/20 0.66
HTR6 P50406 3/20 0.54
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
CA5B Q9Y2D0 1/20 0.46
F10 P00742 3/20 0.46
F12 P00748 1/20 0.46
F7 P08709 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzamidine SCHEMBL21327791 0.83 F2 (0.61) F2CYP1A2TSHRCA12CA1
SCHEMBL77781 0.81 F2 (1.00) F2TMPRSS4TP53CYP1A2CYP2D6
Hypochlorous Acid SCHEMBL17004810 0.80 F2 (0.89) F2TMPRSS4TP53CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL6425431 0.79 F2 (1.00) F2TMPRSS4TP53CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL25973 0.79 F2 (1.00) F2TMPRSS4TP53CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL28825226 0.78 F2 (0.96) F2TMPRSS4TP53CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL723369 0.78 F2 (0.92) F2TMPRSS4TP53CYP1A2CYP2D6
SCHEMBL7106023 0.78 F2 (0.58) F2TMPRSS4TP53CYP1A2CYP2D6
SCHEMBL7815090 0.76 F10 (0.68) F2F10TMPRSS6BLMPRSS1
Hydrochloric Acid SCHEMBL8173513 0.74 F10 (0.65) F2F10TMPRSS6BLMPRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015034056-A1 DISSOCIATION CAPACITY-BOOSTED LIGAND FOR AFFINITY DISSOCIATION MATRIX 株式会社カネカ (JP) 2015-03-12 WO disclosed
WO-2010110288-A1 PROTEIN HAVING AFFINITY FOR IMMUNOGLOBULIN, AND IMMUNOGLOBULIN-BINDING AFFINITY LIGAND 株式会社カネカ (JP) 2010-09-30 WO disclosed