Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135081 | 0.77 | PTGDR2 (0.53) | PTGDR2 | |
| SCHEMBL3427875 | 0.77 | THRA (0.38) | THRATHRBCYP11B1CYP11B2PTGS1 | |
| SCHEMBL152766 | 0.76 | CYP11B1 (0.36) | THRBCYP11B1CYP11B2AKR1C3 | |
| SCHEMBL137342 | 0.69 | PTGDR2 (0.46) | CYP11B1CYP11B2PTGDR2 | |
| SCHEMBL137882 | 0.67 | TRPM8 (0.46) | THRATHRBNPC1RAB9AHSD17B10 | |
| SCHEMBL137354 | 0.66 | PTGDR2 (0.51) | THRATHRBNPC1HSD17B10PTGDR2 | |
| SCHEMBL136380 | 0.66 | CYP11B1 (0.42) | THRBCYP11B1CYP11B2AKR1C3POLB | |
| SCHEMBL153065 | 0.65 | PTGDR2 (0.49) | PTGS1AKR1C3AKR1C2HSD17B10PTGDR2 | |
| SCHEMBL6367068 | 0.64 | PTGS1 (0.51) | THRATHRBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL136371 | 0.62 | CYP11B1 (0.44) | CYP11B1CYP11B2AKR1C3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | claimed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | claimed |