Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513295 | 0.93 | LMNA (0.50) | HTTTDP1LMNAKMT2AMEN1 | |
| SCHEMBL29637044 | 0.87 | NR4A1 (0.54) | HTTLMNANR4A1MAPTALDH1A1 | |
| SCHEMBL511425 | 0.87 | NR4A1 (0.54) | HTTLMNANR4A1MAPTALDH1A1 | |
| SCHEMBL3431001 | 0.81 | ALDH1A1 (0.41) | TDP1LMNAKMT2AMEN1MAPT | |
| SCHEMBL512387 | 0.80 | LMNA (0.49) | HTTTDP1LMNAKMT2AMEN1 | |
| SCHEMBL361807 | 0.80 | IDO1 (0.38) | HTTLMNAKMT2AMEN1MAPT | |
| SCHEMBL361843 | 0.80 | MAPT (0.41) | HTTLMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL17142137 | 0.79 | LMNA (0.39) | HTTTDP1LMNAKMT2AMEN1 | |
| SCHEMBL19812701 | 0.79 | LMNA (0.48) | TDP1LMNAKMT2AMEN1MAPT | |
| SCHEMBL362113 | 0.79 | MAPT (0.41) | HTTLMNAKMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |