Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768259 | 1.00 | LMNA (0.30) | LMNAHPGDTP53 | |
| SCHEMBL3431969 | 0.91 | TP53 (0.31) | TP53 | |
| SCHEMBL3776117 | 0.91 | TP53 (0.31) | TP53 | |
| SCHEMBL3781782 | 0.81 | MAPK1 (0.33) | — | |
| SCHEMBL3770357 | 0.76 | RAPGEF4 (0.30) | — | |
| SCHEMBL3433367 | 0.76 | RAPGEF4 (0.30) | — | |
| SCHEMBL3027938 | 0.70 | GRIN1 (0.33) | LMNAHPGDTP53 | |
| SCHEMBL3027946 | 0.70 | GRIN1 (0.33) | LMNAHPGDTP53 | |
| Hydrochloric Acid SCHEMBL3032341 | 0.69 | GRIN1 (0.33) | LMNAHPGDTP53 | |
| SCHEMBL3434426 | 0.68 | MAPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257535-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009115547-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-09-24 | — | — | WO | disclosed |