Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.40 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427741 | 0.91 | RXFP1 (0.41) | RPA1RXRARXRBRXRGKDR | |
| SCHEMBL3428152 | 0.90 | SLC16A3 (0.50) | SLC16A3SLC16A1RXRARXRBRXRG | |
| SCHEMBL3429822 | 0.88 | RXFP1 (0.39) | RPA1RXRARXRBRXRGKDR | |
| SCHEMBL3427568 | 0.88 | RPA1 (0.46) | RPA1SLC16A3SLC16A1RXRARXRB | |
| SCHEMBL3430605 | 0.86 | RXFP1 (0.43) | RPA1RXFP1POLBALDH1A1BRD9 | |
| SCHEMBL3427610 | 0.86 | RPA1 (0.45) | RPA1KDRRXFP1POLBALDH1A1 | |
| SCHEMBL3434352 | 0.86 | RPA1 (0.39) | RPA1RXRARXRBRXRGKDR | |
| SCHEMBL1764893 | 0.85 | CHRNA7 (0.51) | RPA1RXFP1POLBTP53MALT1 | |
| SCHEMBL3431941 | 0.82 | ALDH1A1 (0.45) | SLC16A3SLC16A1RXRARXRBRXRG | |
| SCHEMBL3423931 | 0.81 | SLC5A1 (0.47) | RPA1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |