Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | LOX | P28300 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958467 | 0.85 | GPR52 (0.63) | GPR52MCL1BCL2L1GRM5 | |
| SCHEMBL957800 | 0.83 | GPR52 (0.50) | GPR52NPC1RAB9AMCL1BCL2L1 | |
| SCHEMBL958528 | 0.83 | GPR52 (0.56) | GPR52MCL1BCL2L1LOXL2GRM5 | |
| SCHEMBL957908 | 0.82 | GPR52 (0.49) | GPR52MCL1BCL2L1GRM5NR1H2 | |
| SCHEMBL964557 | 0.82 | GPR52 (0.50) | GPR52MCL1BCL2L1LOXL2GRM5 | |
| SCHEMBL961526 | 0.79 | MAP4K4 (0.56) | GPR52 | |
| SCHEMBL964554 | 0.78 | LOX (0.49) | GPR52MCL1BCL2L1LOXLOXL2 | |
| SCHEMBL958267 | 0.77 | L3MBTL1 (0.60) | GPR52NPC1RAB9AGRM5NR1H2 | |
| SCHEMBL961657 | 0.77 | MAP4K4 (0.53) | GPR52NPC1RAB9AMCL1BCL2L1 | |
| SCHEMBL959832 | 0.76 | GPR52 (0.46) | GPR52MCL1BCL2L1GRM5SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253618-A1 | COMPOUND HAVING 6-MEMBERED AROMATIC RING | Takeda Pharmaceutical Company Limited (JP) | 2010-11-24 | — | — | EP | disclosed |