Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25614598 | 0.81 | KDM4E (0.40) | LMNANOTUMGRM5KDM4EALDH1A1 | |
| SCHEMBL31635838 | 0.78 | LMNA (0.40) | LMNANOTUMGRM5ERCC1ERCC4 | |
| SCHEMBL4702337 | 0.78 | GRM5 (0.55) | LMNANOTUMGRM5KDM4EALDH1A1 | |
| SCHEMBL27822298 | 0.78 | NOTUM (0.44) | LMNANOTUMGRM5ERCC1ERCC4 | |
| SCHEMBL31635842 | 0.77 | LMNA (0.38) | LMNANOTUMGRM5ERCC1ERCC4 | |
| SCHEMBL5934873 | 0.76 | NOTUM (0.57) | LMNANOTUMGRM5ERCC1ERCC4 | |
| SCHEMBL31635836 | 0.74 | KAT6A (0.38) | LMNANOTUMGRM5ERCC1ERCC4 | |
| Hydrochloric Acid SCHEMBL6006151 | 0.74 | NOTUM (0.55) | LMNANOTUMGRM5ERCC1ERCC4 | |
| SCHEMBL3614755 | 0.74 | GRM5 (0.39) | GRM5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL18946125 | 0.72 | DRD2 (0.44) | GRM5KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247596-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | Natco Pharma Limited (IN) | 2010-11-10 | — | — | EP | claimed |
| WO-2009098715-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-08-13 | — | — | WO | claimed |