Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426753 | 0.94 | MEN1 (0.54) | TAAR1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL10536719 | 0.91 | TAAR1 (0.61) | TAAR1MEN1KMT2AJAK2TYK2 | |
| SCHEMBL3429719 | 0.86 | HTT (0.47) | MEN1KMT2AHTTROCK2ROCK1 | |
| SCHEMBL3429605 | 0.85 | NPC1 (0.56) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3430925 | 0.83 | MEN1 (0.44) | MEN1KMT2AHTTSMN1; SMN2BCAT2 | |
| SCHEMBL3427447 | 0.83 | GRM5 (0.49) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3428051 | 0.83 | MEN1 (0.50) | MEN1KMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL2533213 | 0.82 | MEN1 (0.49) | TAAR1MEN1KMT2AJAK2TYK2 | |
| SCHEMBL3430947 | 0.80 | NPC1 (0.44) | MEN1KMT2AHTTSMN1; SMN2BCAT2 | |
| SCHEMBL1382899 | 0.80 | MEN1 (0.67) | TAAR1MEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |