Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17913821 | 0.88 | MAPT (0.43) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL17028523 | 0.86 | MAPT (0.40) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL19877231 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2248826 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2250472 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL17028515 | 0.82 | MAPT (0.45) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL15322838 | 0.79 | MAPT (0.45) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL15719400 | 0.79 | MAPT (0.45) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL700696 | 0.78 | MAPT (0.44) | MAPTALDH1A1GAASMN1; SMN2NPC1 | |
| SCHEMBL21411461 | 0.76 | ALDH1A1 (0.62) | MAPTALDH1A1GAACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |